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Human Rad51 filaments on double- and solitary-stranded DNA: correlating frequent and irregular forms with recombination functionality.
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Sculpting nano-electrodes by using a transmission electron beam for electrical and geometrical characterization of nanoparticles.
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and initially ever analyze on the dynamics DNA supercoils and the discovery of supercoil hopping
Case in point (3) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is demonstrated in grey, the rim of the pore is highlighted in crimson, along with a 3D rendering of your motion of the DNA rod is exhibited.
We use nanofabricated microfluidic structures to sample spatial boundaries for microbes and biomimetic vesicles with reconstituted protein networks which evaluate the basic part of spatial confinement within the molecular and mobile stage. Our assignments incorporate the next:
2000, discovery that nanotubes can have extraordinary huge present densities; solved the controversial difficulty of electronic transport by DNA molecules by measurements of insulating behavior at The only molecule stage; and demonstration of the AFM method for solitary-molecule manipulation of nanotubes
The rotors harness energy from the nanoscale drinking water and ion movement that is created by a static chemical or electrochemical likely gradient inside the nanopore, which can be proven via a salt gradient or utilized voltage, respectively. These artificial nanoengines self-organize and work autonomously in physiological situations, suggesting ways to developing Electricity-transducing motors at nanoscale interfaces.
It had been during this period that Dekker carried out study on magnetic spin systems and on noise in superconductors and semiconductors.
Screening pseudotopological and nontopological products for SMC-driven DNA loop extrusion cees dekker in opposition to roadblock-traversal experiments
Lots of new phenomena ended up identified, and he and his research team set up a number one placement in this subject of study. Dekker and his investigate team found new physics of nanotubes and explored the feasibility of molecular electronics. In 1998, they ended up the very first to make a transistor based upon a single nanotube molecule.
2005, discovery from the system of DNA uncoiling by topoisomerase enzymes; discovery of long-array conformational modifications in Mre11/DNA repair service complexes; and initial pressure measurements with a DNA molecule within a nanopore
2004, discovery of latest physics in translocation of DNA via nanopores; first experimental review of ions conduction in nanofluidic channels; very first electrochemistry with individual solitary-wall carbon nanotubes; STM detection and Charge of phonons in carbon nanotubes; initially electrical docking of microtubules on kinesin-coated nanostructures; to start with biophysics characterization with the mechanical Homes of double-stranded RNA; and first single-molecule examine of DNA translocation by a restriction-modification enzyme.